Formulation of Controlled Release of Loxacin Tablets Using Natural Polymers

Objective: Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second generation fluoroquinolone. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram positive and Gram negative bacteria. The aim of the present study is to control the release Ofloxacin by formulating a tablet using the natural polymer likes Aloes powder and neem resin (powder). Methods: Tablets were formulated by direct compression technique. The fabricated tablets were evaluated for various pre compressional parameters like angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio and post compressional parameters like average weight, hardness, friability, assay, disintegration time and dissolution studies. Results: In our present study, the effect of Aloes powder and neem resin (powder) with Ofloxacin is studied. The pre-compression and post compression parameters were found to be satisfactory. The results proved that at higher proportion of neem resin (powder) ratio, the drug release was prolonged than the lower proportion. Conclusion: The results of the present study showed that ofloxacin may be formulated as controlled release tablets by using the natural polymers aloes and neem resins.